The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents

Autor:	M G, Siegel, A J, Shuker, C A, Droste, P J, Hahn, C D, Jesudason, J H, McDonald, D P, Matthews, C J, Rito, A J, Thorpe
Rok vydání:	1997
Předmět:	Adrenergic Antagonists Molecular Structure Ethanolamines Amines Ketones Chromatography Ion Exchange Adrenergic Agonists Receptors Adrenergic
Zdroj:	Molecular diversity. 3(2)
ISSN:	1381-1991
Popis:	A library of potential agonists and antagonists for adrenergic receptors was prepared using high-throughput solution-phase parallel synthesis. Traditional solution-phase reductive amination reactions followed by rapid purification by ion exchange chromatography yielded products with near-analytical purity. An array of ketones and amines, arranged in an 8 x 12 matrix, were combined to form 96 individual compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cdfffac13b9a7c847980ec5c70e34616 https://pubmed.ncbi.nlm.nih.gov/9593180 Zobrazit plný text záznamu Full text from SpringerLink