Epidermal growth factor family in rhesus monkey uterus during the menstrual cycle and early pregnancy
| Autor: | Z P, Yue, Z M, Yang, S J, Li, H B, Wang, M J, Harper |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Epidermal Growth Factor
Uterus Transforming Growth Factor alpha Amphiregulin Immunohistochemistry Macaca mulatta ErbB Receptors Pregnancy Animals Intercellular Signaling Peptides and Proteins Pregnancy Animal Female Growth Substances Menstrual Cycle Glycoproteins Heparin-binding EGF-like Growth Factor |
| Zdroj: | Molecular reproduction and development. 55(2) |
| ISSN: | 1040-452X |
| Popis: | This study examines immunohistochemically the presence of EGF, TGFalpha, HB-EGF, AR, and EGFR, members of the EGF family in the monkey uterus during the menstrual cycle and early pregnancy. EGF, TGFalpha, HB-EGF, AR, and EGFR were mainly localized in glandular and luminal epithelium. TGFalpha, HB-EGF, and AR staining were stronger in the glandular epithelium closer to the myometrium than in that closer to the luminal epithelium. The level of EGF, TGFalpha, HB-EGF, AR, and EGFR staining was low on days 1 and 6, and began to increase on day 9 of the menstrual cycle. A high level of EGF, and EGFR staining was maintained on days 16, 20, and 25 of the menstrual cycle. The highest levels of TGFalpha, AR, and HB-EGF staining were seen on days 16 and 20 of the menstrual cycle. In early pregnancy, a low level of EGF, TGFalpha, HB-EGF, AR, and EGFR staining appeared on days 1 and 2 of pregnancy, and then gradually increased from day 3 of pregnancy. The highest levels of EGF, TGFalpha, HB-EGF, and EGFR were detected on days 9, and 11 of pregnancy. Our data suggest that the EGF family may play a role in monkey implantation. Mol. Reprod. Dev. 55:164-174, 2000. |
| Databáze: | OpenAIRE |
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