Influence of subinhibitory concentrations of licochalcone A on the secretion of enterotoxins A and B by Staphylococcus aureus

Autor:	Jiazhang, Qiu, Haihua, Feng, Hua, Xiang, Dacheng, Wang, Lijie, Xia, Youshuai, Jiang, Keji, Song, Jing, Lu, Lu, Yu, Xuming, Deng
Rok vydání:	2010
Předmět:	Male Mice Inbred BALB C Staphylococcus aureus Dose-Response Relationship Drug Tumor Necrosis Factor-alpha T-Lymphocytes Blotting Western Gene Expression Enterotoxins Mice Chalcones Animals Spleen Cell Proliferation
Zdroj:	FEMS microbiology letters. 307(2)
ISSN:	1574-6968
Popis:	Enterotoxins produced by Staphylococcus aureus are the key pathogenicity factors that can cause a variety of illnesses in humans, including staphylococcal gastroenteritis and food poisoning. It has been proven that licochalcone A is a potentially effective antimicrobial agent against S. aureus. In this study, Western blot assays, tumour necrosis factor release assays, murine T-cell proliferation assays, and real-time reverse transcriptase-PCR were performed to evaluate the effect of subinhibitory concentrations of licochalcone A on the secretion of two major enterotoxins (SEA and SEB) by S. aureus. The results show that licochalcone A significantly decreased, in a dose-dependent manner, the secretion of SEA and SEB by both methicillin-sensitive S. aureus and methicillin-resistant S. aureus. These results may increase the desirability of using licochalcone A as a lead compound for the design of more potent antibacterial agents based on the chalcone template.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cd74590d98b2b9b3dd34cb80fbf89fc0 https://pubmed.ncbi.nlm.nih.gov/20412304 Zobrazit plný text záznamu Plný text