Association between femur size and a focal defect of the superior femoral neck
| Autor: | A H, Gee, G M, Treece, C J, Tonkin, D M, Black, K E S, Poole |
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| Rok vydání: | 2015 |
| Předmět: |
Aged
80 and over Male Femur Neck Osteoporotic fractures Original Full Length Article Hip structure analysis Organ Size Middle Aged Adaptation Physiological Femoral Neck Fractures Bone Density Risk Factors Humans Radiographic Image Interpretation Computer-Assisted Female Femur Tomography X-Ray Computed Cortical bone mapping Aged |
| Zdroj: | Bone |
| ISSN: | 1873-2763 |
| Popis: | Within each sex, there is an association between hip fracture risk and the size of the proximal femur, with larger femurs apparently more susceptible to fracture. Here, we investigate whether the thickness and density of the femoral cortex play a role in this association: might larger femurs harbour focal, cortical defects? To answer this question, we used cortical bone mapping to measure the distribution of cortical mass surface density (CMSD, mg/cm2) in cohorts of 308 males and 125 females. Principal component analysis of the various femoral surfaces led to a measure of size that is linearly independent from shape. After mapping the data onto a canonical femur surface, we used statistical parametric mapping to identify any regions where CMSD depends on size, allowing for other confounding covariates including shape. Our principal finding was a focal patch on the superior femoral neck, where CMSD is reduced by around 1% for each 1% increase in proximal-distal size (p Highlights • We analysed QCT scans of the proximal femurs of 308 males and 125 females. • We mapped the cortical mass surface density (CMSD) across each proximal femur. • In a focal patch on the superior femoral neck, CMSD decreases as femur size increases. • This finding is consistent with models of functional adaptation and fracture risk. |
| Databáze: | OpenAIRE |
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