[Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Review]
| Autor: | Jorge, García-Tamayo, Julia, Molina, Eduardo, Blasco-Olaetxea |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Gene Expression Regulation
Viral Genes Viral Gene Expression Profiling Papillomavirus Infections Uterine Cervical Neoplasms Oncogene Proteins Viral Prognosis Uterine Cervical Dysplasia Neoplasm Proteins Gene Expression Regulation Neoplastic Mutation Biomarkers Tumor Blood Group Antigens Carcinoma Squamous Cell Humans Female Papillomaviridae Genes Neoplasm |
| Zdroj: | Investigacion clinica. 50(2) |
| ISSN: | 0535-5133 |
| Popis: | Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review. A variety of proteins like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, beta-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papilloma virus infection. It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV). |
| Databáze: | OpenAIRE |
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