4‐Aminopyridine: a pan voltage‐gated potassium channel inhibitor that enhances Kv7.4 currents and inhibits noradrenaline‐mediated contraction of rat mesenteric small arteries

Autor:	Khammy, Makhala M, Kim, Sukhan, Bentzen, Bo H, Lee, Soojung, Choi, Inyeong, Aalkjær, Christian, Jepps, Thomas A
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male Dose-Response Relationship Drug KCNQ Potassium Channels Research Papers Mesenteric Arteries Rats Norepinephrine Xenopus laevis HEK293 Cells Organ Culture Techniques Vasoconstriction Potassium Channel Blockers Animals Humans Female 4-Aminopyridine Rats Wistar
Popis:	KVoltage clamp experiments were performed on Xenopus laevis oocytes injected with cRNA encoding KCNQ4 or KCNQ5, HEK cells expressing K4-AP increased the KThese data show that 4-AP is able to relax NA-preconstricted rat mesenteric arteries by enhancing the activity of K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cd4207eccaac43bc774aa47ab5ebe683 https://europepmc.org/articles/PMC5773965/ Zobrazit plný text záznamu