New minimally invasive model of spinal cord ischemia in rats

Autor:	G Z, Sufianova, L A, Usov, A A, Sufianov, A G, Shapkin, L Yu, Raevskaya
Rok vydání:	2001
Předmět:	Disease Models Animal Spinal Cord Ischemia Aortic Diseases Animals Female Aorta Abdominal Rats
Zdroj:	Bulletin of experimental biology and medicine. 133(1)
ISSN:	0007-4888
Popis:	We developed a new minimally invasive model of spinal cord ischemia in rats: intravascular occlusion of the abdominal aorta and its branches. This model can be used on small laboratory animals and allows qualitatively and quantitatively evaluating the morphofunctional state of the nervous system during spinal cord ischemia by clinical manifestations and histological changes. Selective intravascular occlusion determines minimal invasiveness and adequacy of the proposed model to in vivo pathological processes. This model of spinal cord ischemia can be used in experimental pharmacology for evaluation of neuroprotective activity of various drugs and bioactive substances.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cd0cd4326ded6d3e2009079b6b8877bb https://pubmed.ncbi.nlm.nih.gov/12170319 Zobrazit plný text záznamu Full text from SpringerLink