Effects of blood flow on the antibacterial efficacy of chlorhexidine and silver sulfadiazine coated central venous catheter
| Autor: | Cui, Yong Huan, Choi, Yoon Ji, Kim, Eung Hwi, Yu, Joon Ho, Seong, Hyun Young, Choi, Sung-uk, Yoon, Seung Zhoo, Huh, Hyub |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
catheter-related bloodstream infection
Catheterization Central Venous Chlorhexidine Pilot Projects Clinical Trial/Experimental Study equipment and supplies Models Biological Silver Sulfadiazine Anti-Bacterial Agents antibacterial activity Catheter-Related Infections Anti-Infective Agents Local Central Venous Catheters Humans bloodstream model Blood Flow Velocity Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: Chlorhexidine and silver sulfadiazine coated central venous catheters (CSS-CVC) may cause loss of antimicrobial efficacy due to friction between the CVC surface and sheer stress caused by the blood flow. Therefore, the aim of this study was to investigate the antibacterial efficacy of CSS-CVC at various flow rates using a bloodstream model. Methods: Each CVC was subjected to various flow rates (0.5, 1, 2, and 4 L/min) and wear-out times (0, 24, 48, 72, 96, and 120 hours), and the optical density (OD) 600 after a Staphylococcus aureus incubation test was used to determine the antibacterial effect of CSS-CVC. Results: In the 0.5 L/min group, there was no significant change in the OD600 value up to 120 hours compared with the baseline OD600 value for CSS-CVC (P > .467). However, the OD600 values of CSS-CVC in the 1 L/min (P |
| Databáze: | OpenAIRE |
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