Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence

Autor:	I, Prigione, F, Morandi, M A, Tosca, M, Silvestri, V, Pistoia, G, Ciprandi, G A, Rossi
Rok vydání:	2009
Předmět:	Male Rhinitis Allergic Seasonal Th1 Cells T-Lymphocytes Regulatory Asthma Interleukin-10 Up-Regulation Interferon-gamma Hypersensitivity Cytokines Humans Female Child Follow-Up Studies
Zdroj:	Allergy. 65(6)
ISSN:	1398-9995
Popis:	A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients.It was to investigate the possible role of Treg-Th1 cytokines, in the development of new sensitizations in childhood.Forty monosensitized (MS) children with allergic rhinitis were evaluated and followed-up for 2 years. New sensitizations were investigated. IL-10 and IFN-gamma were evaluated in in vitro experiments.Children remaining MS showed significant higher production of both IL-10 and IFN-gamma.This preliminary study provided evidence that IL-10 and IFN-gamma production could be defective in allergic children prone to develop polysensitization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ccd3af071d9a087655a148cc4e765253 https://pubmed.ncbi.nlm.nih.gov/19958312 Zobrazit plný text záznamu Plný text