| Autor: |
Robert, Pola, Eva, Pokorná, Petra, Vočková, Eliška, Böhmová, Michal, Pechar, Jana, Karolová, Jan, Pankrác, Luděk, Šefc, Karel, Helman, Marek, Trněný, Tomáš, Etrych, Pavel, Klener |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Acta biomaterialia. 119 |
| ISSN: |
1878-7568 |
| Popis: |
Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma (B-NHL) with chronically relapsing clinical course. Implementation of cytarabine (araC) into induction and salvage regimen became standard of care for majority of MCL patients. In this study, tailored N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer nanotherapeutics containing covalently bound araC (araC co-polymers) were designed, synthesized and evaluated for their anti-lymphoma efficacy in vivo using a panel of six patient-derived lymphoma xenografts (PDX) derived from newly diagnosed and relapsed / refractory (R/R) MCL. While free araC led to temporary inhibition of growth of MCL tumors, araC co-polymers induced long-term disappearance of the engrafted lymphomas with no observed toxicity even in the case of PDX models derived from patients, who relapsed after high-dose araC-based treatments. The results provide sound preclinical rationale for the use of HPMA-based araC co-polymers in induction, salvage or palliative therapy of MCL patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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