[A case of hepatocellular carcinoma with bone metastasis responding to concurrent TS-1/low-dose cisplatin (CDDP) therapy and radiotherapy]
| Autor: | Toshiyuki, Suganuma, Risa, Terauchi, Atsushi, Shikina, Masafumi, Tanaka, Suefumi, Aozasa, Katsuyuki, Utsunomiya, Keiichi, Fujino, Hideto, Ito, Kazushige, Okada, Tomoki, Tsuda, Kazuo, Hase |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Carcinoma Hepatocellular Dose-Response Relationship Drug Pyridines Liver Neoplasms Bone Neoplasms Middle Aged Drug Administration Schedule Drug Combinations Oxonic Acid Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Hepatectomy Humans Infusions Intra-Arterial Prothrombin alpha-Fetoproteins Cisplatin Protein Precursors Biomarkers Tegafur |
| Zdroj: | Gan to kagaku ryoho. Cancerchemotherapy. 31(5) |
| ISSN: | 0385-0684 |
| Popis: | A standard treatment for hepatocellular carcinoma with extrahepatic metastasis is not established and chemotherapy is ineffective. We experienced a case of hepatocellular carcinoma with bone metastasis that responded to concurrent TS-1/low-dose cisplatin (CDDP) therapy and radiotherapy. A 58-year-old male patient with left iliac bone metastasis after 2 hepatectomies was admitted to our hospital. The titer of serum AFP and PIVKA-II showed an extremely high levels, 12,350.5 ng/ml and 993 mAU/ml, respectively. The uptake area was found at the left iliac bone by scintigraphy with 99mTc-HMDP. Treatment with TS-1/low-dose CDDP therapy and radiotherapy (36 Gy) was started concurrently. The chemotherapy regimen comprised daily oral administration of 100 mg of TS-1 for 21 days and CDDP 10 mg/body infusion (day 1-5, 8-12). An additional 2 courses of TS-1/low-dose CDDP therapy were repeated. After that, severe pain diminished and the titer of serum showed AFP and PIVKA-II had improved to within normal ranges. The uptake at the left iliac bone was found to have decreased by scintigraphy. Adverse events were grade 1 nausea and leucopenia. TS-1/low-dose CDDP therapy seems to be applicable for the treatment of hepatocellular carcinoma with bone metastasis. |
| Databáze: | OpenAIRE |
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