| Autor: |
G H, Borgström, I, Elomaa, C, Blomqvist, L, Porkka |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Bone. 8 |
| ISSN: |
8756-3282 |
| Popis: |
In order to judge whether or not clodronate used for treatment of patients with Paget's disease of bone had an effect on the haematopoetic tissue, the frequency of chromosome/chromatid breaks in bone marrows and blood cells was evaluated. Seven patients were studied before treatment, after a few days of treatment and after greater than or equal to 2 months of treatment. Three additional patients were studied after exposure to clodronate for greater than or equal to 6 months. There was no significant increase in the occurrence of chromosomal aberrations induced by treatment. Thus no negative effect of clodronate on the haematopoetic tissue could be noted. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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