| Autor: |
G F, Makarova, O I, Epifanova, B V, Loginov, L B, Gorbacheva |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Tsitologiia. 29(2) |
| ISSN: |
0041-3771 |
| Popis: |
The lethal effect of antitumor nitrosourea chloroethyl derivatives on proliferating (exponential phase of growth) and non-proliferating (stationary phase of growth) cells is observed at a concentration 5-fold less than that of methyl derivatives revealed by the colony-formation technique. 1,3-bis(2-chlororoethyl)-1-nitrosourea is equally effective towards proliferating and non-proliferating cells, but chlorozotocin exerts a primary cytotoxic effect on proliferating cells. 1-methyl-1-nitrosourea at low concentration causes death more readily of proliferating cells than non-proliferating ones. However, studies on proliferative activity during the first hours after treatment with 1-methyl-1-nitrosourea revealed drug sensitivity in cells being at the early stationary phase of growth. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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