| Autor: |
E R, DeSombre, P V, Harper, A, Hughes, R C, Mease, S J, Gatley, O T, DeJesus, J L, Schwartz |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Cancer research. 48(20) |
| ISSN: |
0008-5472 |
| Popis: |
While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a key component we studied the 4.4-h half-life, Auger electron-emitting nuclide bromine-80m. When incorporated into DNA this nuclide was radiotoxic to cells in culture and caused substantial chromosomal damage, while similar concentrations of bromine-80m as bromide or bromoantipyrine were without effect. The mean lethal dose for bromine-80m was 45 atoms per nucleus which is consistent with use in receptor-positive cancers with limited numbers of ER. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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