Evaluation of the MycoDot test for the diagnosis of tuberculosis in HIV seropositive and seronegative patients
| Autor: | W, Ratanasuwan, J K, Kreiss, C M, Nolan, B A, Schaeffler, S, Suwanagool, S, Tunsupasawasdikul, C, Chuchottaworn, W, Dejsomritrutai, H M, Foy |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Lipopolysaccharides Male AIDS-Related Opportunistic Infections Adolescent Mycobacterium tuberculosis Middle Aged Thailand Antibodies Bacterial Sensitivity and Specificity Cross-Sectional Studies HIV Seronegativity HIV Seropositivity Humans Female Reagent Kits Diagnostic Developing Countries Tuberculosis Pulmonary Aged |
| Zdroj: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 1(3) |
| ISSN: | 1027-3719 |
| Popis: | Patients were recruited from Siriraj, Bamrasnaradura, and Central Chest Hospitals, the three major hospitals responsible for tuberculosis patients in Bangkok, Thailand, and vicinity.To evaluate a new rapid serologic test, the MycoDot test, for diagnosis of tuberculosis (TB).The study was conducted as a cross-sectional survey. A total of 594 patients were tested with the MycoDot test. This included 142 human immunodeficiency virus (HIV) seropositive patients with active TB, 144 HIV seronegative patients with active TB, 153 HIV seropositive controls, and 155 HIV seronegative controls.The sensitivity of the MycoDot test for detection of TB was 40.1% in HIV seropositive patients, compared with 63.2% in HIV seronegative patients (P0.001). If only patients with laboratory proven TB were evaluated, the sensitivity was 40.6% in seropositive and in 70.8% seronegative patients. The sensitivity of the MycoDot test was similar in TB patients with pulmonary and extra-pulmonary disease. The sensitivity of the test in patients with CD4 countsor = 200 cells/mm3 was significantly higher than in those with CD4 counts200 cells/mm3. The specificity of the test was 97.4%, and was identical in HIV seropositive and seronegative individuals.The MycoDot test had a higher sensitivity for the diagnosis of TB among HIV seronegative than HIV seropositive patients. Although the MycoDot test has a less than optimal sensitivity, the test specificity approaches 100%. It may be useful in patients with suspected TB and negative smears and in extra-pulmonary TB. |
| Databáze: | OpenAIRE |
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