HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus
| Autor: | G L, Semenza |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cell Nucleus
Procollagen-Proline Dioxygenase Nuclear Proteins Helminth Proteins Hypoxia-Inducible Factor 1 alpha Subunit Cell Hypoxia DNA-Binding Proteins Oxygen Gene Expression Regulation Animals Homeostasis Humans Hypoxia-Inducible Factor 1 Caenorhabditis elegans Proteins Signal Transduction Transcription Factors |
| Zdroj: | Cell. 107(1) |
| ISSN: | 0092-8674 |
| Popis: | Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation. |
| Databáze: | OpenAIRE |
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