Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia
| Autor: | S, François, E, Delabesse, L, Baranger, M, Dautel, C, Foussard, M, Boasson, O, Blanchet, O, Bernard, E A, Macintyre, N, Ifrah |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Gene Expression DNA Neoplasm Translocation Genetic DNA-Binding Proteins Gene Expression Regulation Neoplastic Chromosomes Human Pair 1 Karyotyping Proto-Oncogene Proteins Basic Helix-Loop-Helix Transcription Factors Chromosomes Human Pair 5 Humans Leukemia-Lymphoma Adult T-Cell RNA Messenger T-Cell Acute Lymphocytic Leukemia Protein 1 Transcription Factors |
| Zdroj: | Genes, chromosomescancer. 23(1) |
| ISSN: | 1045-2257 |
| Popis: | TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL1, in which the breakpoint occurs approximately 10kbp 5' to the gene and leads to transcriptional activation and synthesis of a TAL1 protein, and extends the spectrum of recognized TAL1 gene translocations associated with T-ALL. |
| Databáze: | OpenAIRE |
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