| Autor: |
Murphy, Malia S Q, Hawken, Steven, Atkinson, Katherine M, Milburn, Jennifer, Pervin, Jesmin, Gravett, Courtney, Stringer, Jeffrey S A, Rahman, Anisur, Lackritz, Eve, Chakraborty, Pranesh, Wilson, Kumanan |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
BMJ Global Health |
| ISSN: |
2059-7908 |
| Popis: |
Background Knowledge of gestational age (GA) is critical for guiding neonatal care and quantifying regional burdens of preterm birth. In settings where access to ultrasound dating is limited, postnatal estimates are frequently used despite the issues of accuracy associated with postnatal approaches. Newborn metabolic profiles are known to vary by severity of preterm birth. Recent work by our group and others has highlighted the accuracy of postnatal GA estimation algorithms derived from routinely collected newborn screening profiles. This protocol outlines the validation of a GA model originally developed in a North American cohort among international newborn cohorts. Methods Our primary objective is to use blood spot samples collected from infants born in Zambia and Bangladesh to evaluate our algorithm’s capacity to correctly classify GA within 1, 2, 3 and 4 weeks. Secondary objectives are to 1) determine the algorithm's accuracy in small-for-gestational-age and large-for-gestational-age infants, 2) determine its ability to correctly discriminate GA of newborns across dichotomous thresholds of preterm birth (≤34 weeks |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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