Integrated multi-omic characterization of congenital heart disease

Autor:	Matthew C, Hill, Zachary A, Kadow, Hali, Long, Yuka, Morikawa, Thomas J, Martin, Emma J, Birks, Kenneth S, Campbell, Jeanne, Nerbonne, Kory, Lavine, Lalita, Wadhwa, Jun, Wang, Diwakar, Turaga, Iki, Adachi, James F, Martin
Rok vydání:	2021
Předmět:	Cardiomyopathy Dilated Heart Defects Congenital Forkhead Transcription Factors YAP-Signaling Proteins Bone Morphogenetic Protein Receptors Cardiomyopathy Hypertrophic Fibroblasts Monocytes Phenotype Hypoplastic Left Heart Syndrome Disease Progression Tetralogy of Fallot Humans Myocytes Cardiac RNA-Seq Insulin Resistance Single-Cell Analysis Image Cytometry Signal Transduction
Zdroj:	Nature. 608(7921)
ISSN:	1476-4687
Popis:	The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of patients with CHD survive into adulthood, but many suffer premature death from heart failure and non-cardiac causes
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cbdc4025b7dada81338add3000cf2231 https://pubmed.ncbi.nlm.nih.gov/35817872 Zobrazit plný text záznamu Full text from SpringerLink