| Autor: |
Caroline, Diveu, Anne-Hélène Lagrue, Lak-Hal, Josy, Froger, Elisa, Ravon, Linda, Grimaud, Fabien, Barbier, Jacques, Hermann, Hugues, Gascan, Sylvie, Chevalier |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
European cytokine network. 15(4) |
| ISSN: |
1148-5493 |
| Popis: |
Gp130-like receptor (GPL) is a newly identified cytokine receptor. A recent study reported the involvement of GPL, together with OSMR, in the formation of the receptor complex for IL-31, a novel immune cytokine with a skin tropism. In the present work, we analyzed the signaling properties of IL-31 in glioblastoma and melanoma tumor cells. We demonstrate that in response to IL-31, its receptor complex recruits Jak1, Jak2, STAT1, -3, -5 signaling pathways, as well as the Pi3 kinase / AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Different responses were observed depending on the expression of short or long GPL receptor isoform within the studied cell lines. We show that the short form of GPL receptor exerts a profound inhibitory effect on the signaling of IL-31 and behaves as a dominant negative receptor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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