| Autor: |
Thi My Lien, Do, Anh Vu, Truong, Travis George, Pinnock, Lawrence Michael, Pratt, Shigeki, Yamamoto, Hitoshi, Watarai, Dominique, Guillaume, Kim Phi Phung, Nguyen |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Chemicalpharmaceutical bulletin. 61(6) |
| ISSN: |
1347-5223 |
| Popis: |
From the aerial part of Boerhaavia erecta L., three new rotenoids (3, 8, 10) and two new coumaronochromonoids (6, 11) were isolated, together with ten known compounds. The structure of the new compounds was established by one dimensional (1D)- and 2D-NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of compound 11 was determined by UV circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 µg/mL. Rotenoids 3, 4 and 5 showed a strong cytotoxic activity against HeLa cell line and rotenoids 5 and 8 showed good activity against MCF-7 cell line. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
