| Autor: |
Jamshaid, Ashraf, Ehsan Ullah, Mughal, Reem I, Alsantali, Amina, Sadiq, Rabab S, Jassas, Nafeesa, Naeem, Zaman, Ashraf, Yasir, Nazir, Muhammad Naveed, Zafar, Amara, Mumtaz, Masoud, Mirzaei, Satar, Saberi, Saleh A, Ahmed |
| Rok vydání: |
2021 |
| Zdroj: |
RSC advances. 11(56) |
| ISSN: |
2046-2069 |
| Popis: |
The excelling role of organic chemistry in the medicinal field continues to be one of the main leads in the drug development process. Particularly, this industry requires organic chemists to discover small molecular structures with powerful pharmacological potential. Herein, a diverse range of chalcone (1-11) and aurone (12-22) derivatives was designed and synthesized and for the first time, and both motifs were evaluated as potent inhibitors of alkaline phosphatases (APs). Structural identification of the target compounds (1-22) was accomplished using common spectroscopic techniques. The effect of the nature and position of the substituent was interestingly observed and justified based on the detailed structure-activity relationship (SAR) of the target compounds against AP. It was concluded from the obtained results that all the newly synthesized compounds exhibit high inhibitory potential against the AP enzyme. Among them, compounds 12 (IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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