| Autor: |
Fatemeh, Heidary, Mehdi, Tourani, Fatemeh, Hejazi-Amiri, Seyyed Hossein, Khatami, Navid, Jamali, Mortaza, Taheri-Anganeh |
| Rok vydání: |
2022 |
| Zdroj: |
Molecular biology research communications. 11(1) |
| ISSN: |
2345-2005 |
| Popis: |
Lung cancer is the most common type of tumor worldwide. Non-small-cell lung carcinoma (NSCLC) is considered any epithelial cell-related lung cancer, which includes more than 85% of all lung cancer cases. NSCLC is less responsive to chemotherapy than SCLC. Therefore, the need for other treatments has become more pronounced and immunotherapy has gained increasing attention as a promising therapy in recent years. The current study aimed to design a multi-epitope peptide vaccine targeting main cancer/testis antigens of SP17, AKAP4, and PTTG1, which have a major function in tumor cell proliferation invasion. The protein vaccine was constructed using the rigorous immunoinformatics analysis and investigation of several immune system parameters, considering B cell epitopes and CD4 and CD8 induced epitopes as the most important cells to respond to cancer cells. Inverse translation and optimization of codons were performed to have the designed protein's cloning as well as expression potential in |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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