Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma

Autor:	T A, Korolenko, S Ya, Zhyanaeva, O N, Poteryaeva, O V, Falameeva, O A, Levina, V I, Kaledin, I, Shandula
Rok vydání:	2001
Předmět:	Male Mice Inbred C57BL Carcinoma Lewis Lung Mice Liver Lymphoma Non-Hodgkin Biomarkers Tumor Mice Inbred CBA Animals Prognosis Spleen Cathepsin B
Zdroj:	Bulletin of experimental biology and medicine. 133(4)
ISSN:	0007-4888
Popis:	We measured activity and content of cathepsin B in tumor tissues, liver, and spleen in mice with Lewis adenocarcinoma and LS-lymphosarcoma. Cathepsin B activity in Lewis adenocarcinoma cells was lower than in LS-lymphosarcoma cells, which was probably related to differences in their metastatic properties. Antitumor therapy increased activity and content of cathepsin B in tumor tissues. Changes in the content and activity of cathepsin B in tumor tissues can serve as a prognostic criterion for tumor regression during therapy. Cathepsin B is probably involved in apoptosis of tumor cells during chemotherapy of lymphosarcoma-LS with cyclophosphamide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cb5a95027e5c3332f845a2c0405c992e https://pubmed.ncbi.nlm.nih.gov/12124655 Zobrazit plný text záznamu Full text from SpringerLink