Transcriptom-based identification of a putative role for the human Acyl-CoA-Binding-Protein (ACBP) in vesicular trafficking

Autor:	C, Vock, I, Nitz, F, Döring
Rok vydání:	2009
Předmět:	Diazepam Binding Inhibitor Gene Expression Profiling Humans Biological Transport RNA Interference Endosomes Hep G2 Cells RNA Small Interfering rhoB GTP-Binding Protein Adaptor Proteins Signal Transducing Signal Transduction
Zdroj:	Cellular and molecular biology (Noisy-le-Grand, France).
ISSN:	1165-158X
Popis:	In the present study we performed a transcriptom-based analysis of human Acyl-CoA-Binding-Protein (ACBP) target genes. By applying Genomatix BiblioSphere expert level based co-citation filter 4 (GFG level 4) ras homolog gene family member B (RhoB) and its interacting rhophilin-2 (Rhpn2) were refined from 64 ACBP sensitive genes. TaqMan-based qRT-PCR confirmed the accuracy of the array-derived expression data. Based on Gene Ontology (GO) classification RhoB and Rhnp2 were allocated to endosomal transport and signaling processes. Thus, we suggest RhoB and Rhnp2 as ACBP target genes contributing to the proposed and evolutionary conserved function of ACBP in vesicular transport processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cb54271bfdd7d89aba3d2cc32b58f4a5 https://pubmed.ncbi.nlm.nih.gov/20219168 Zobrazit plný text záznamu