Haemostatic role of intermediate filaments in adhered platelets: importance of the membranous system stability

Autor:	Doris, Cerecedo, Ivette, Martínez-Vieyra, Ricardo, Mondragón, Mónica, Mondragón, Sirenia, González, Iván J, Galván
Rok vydání:	2013
Předmět:	Blood Platelets Microscopy Electron Platelet Adhesiveness Blotting Western Dystrophin-Associated Proteins Intermediate Filaments Fluorescent Antibody Technique Humans Immunoprecipitation Plectin Vimentin Microtubules Desmin
Zdroj:	Journal of cellular biochemistry. 114(9)
ISSN:	1097-4644 2050-2060
Popis:	The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored. J. Cell. Biochem. 114: 2050-2060, 2013. © 2013 Wiley Periodicals, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::cb31a7ec0c67363257a149dd5d185e95 https://pubmed.ncbi.nlm.nih.gov/23553987 Zobrazit plný text záznamu Plný text