| Autor: |
S V, Krapivin, N N, Bogdanov, K E, Voronin |
| Rok vydání: |
1988 |
| Předmět: |
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| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny. 106(7) |
| ISSN: |
0365-9615 |
| Popis: |
The influence of some drugs (piracetam and 3-oxypyridine derivative) having a nootropic effect on ethanol-induced changes of bioelectrical activity was studied in experiments on freely moving rats. Discontinuation of ethanol administration (1, 2 g/kg, i.p. for 40 days) has been found to provoke destructuring of Fourier's spectral power of sensorimotor cortex and dorsal hippocamp on the EEG. Long-term administration of piracetam or 3-oxypyridine derivative (300 and 50 mg/kg, respectively, i.p. for 40 days) with ethanol has a protective effect and normalizes EEG at the cortical level. The authors discuss possible neurophysiological mechanisms of nootropic drug action in ethanol-induced pathology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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