| Autor: |
David, Gate, Emma, Tapp, Olivia, Leventhal, Marian, Shahid, Tim J, Nonninger, Andrew C, Yang, Katharina, Strempfl, Michael S, Unger, Tobias, Fehlmann, Hamilton, Oh, Divya, Channappa, Victor W, Henderson, Andreas, Keller, Ludwig, Aigner, Douglas R, Galasko, Mark M, Davis, Kathleen L, Poston, Tony, Wyss-Coray |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Science (New York, N.Y.). 374(6569) |
| ISSN: |
1095-9203 |
| Popis: |
Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is unknown. Here, we observed T cells adjacent to Lewy bodies and dopaminergic neurons in postmortem LBD brains. Single-cell RNA sequencing of cerebrospinal fluid (CSF) identified up-regulated expression of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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