| Autor: |
Carla, Azevedo, Gabriel, Teku, Yuriy, Pomeshchik, Juan F, Reyes, Margarita, Chumarina, Kaspar, Russ, Ekaterina, Savchenko, Anna, Hammarberg, Nuno Jorge, Lamas, Anna, Collin, Gunnar K, Gouras, Oxana, Klementieva, Martin, Hallbeck, Ricardo, Taipa, Mauno, Vihinen, Laurent, Roybon |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 119(12) |
| ISSN: |
1091-6490 |
| Popis: |
SignificanceOur results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy. The knowledge generated in this study could be used to devise novel therapeutic approaches to treat synucleinopathies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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