| Autor: |
Liciane Fernandes, Medeiros, Éllen Almeida, Nunes, Bettega Costa, Lopes, Andressa, de Souza, Angélica Regina, Cappellari, Joice Soares, de Freitas, Isabel Cristina, de Macedo, Jonnsin, Kuo, Stefania Giotti, Cioato, Ana Maria de Oliveira, Battastini, Wolnei, Caumo, Iraci L S, Torres |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceREFERENCES. 80(7) |
| ISSN: |
1873-474X |
| Popis: |
This study assessed the effects of an acute stress model upon the long-term hyperalgesia induced by repeated morphine administration in neonatal rats. We also evaluated neurotrophins and cytokines levels; expressions of adenosine and acetylcholine receptors, and acetylcholinesterase enzyme at the spinal cord.Male Wistar rats were subjected to morphine or saline administration from P8 to P14. Thermal hyperalgesia and mechanical hyperesthesia were assessed using the hot plate (HP) and von Frey (vF) tests, respectively, at postnatal day P30 and P60. After baseline measurements, rats were subjected to a single exercise session, as an acute stress model, at P30 or P60. We measured the levels of BDNF and NGF, interleukin-6, and IL-10 in the cerebral cortex and the brainstem; and the expression levels of adenosine and muscarinic receptors, as well as acetylcholinesterase (AChE) enzyme at the spinal cord.A stress exercise session was not able to revert the morphine-induced hyperalgesia. The morphine and exercise association in rats induced a decrease in the neurotrophins brainstem levels, and ASingle session of exercise does not revert hyperalgesia induced by morphine in rats; however, morphine plus exercise modulate neurotrophins, IL-6 central levels, and expression of adenosine receptors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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