Breast conservation in elderly women for clinically negative axillary lymph nodes without axillary dissection

Autor:	D E, Wazer, J K, Erban, N J, Robert, T J, Smith, D J, Marchant, C, Schmid, T, DiPetrillo, R, Schmidt-Ullrich
Rok vydání:	1994
Předmět:	Aged 80 and over Age Factors Breast Neoplasms Combined Modality Therapy Survival Rate Treatment Outcome Axilla Humans Female Lymph Nodes Prospective Studies Aged Follow-Up Studies Neoplasm Staging
Zdroj:	Cancer. 74(3)
ISSN:	0008-543X
Popis:	A prospective study was initiated to explore an approach of limited therapy in elderly patients with early clinical stage breast cancer.Between 1982 and 1989, 73 women with American Joint Committee on Cancer Stage I/II, clinically negative axillary lymph nodes aged 65 years or older (median age, 74 years) were enrolled in a treatment program consisting of tumor excision, breast and regional lymph node irradiation, and, in 66 patients, tamoxifen. Patients were assessed for disease outcome and complications.At a median follow-up of 54 months, 8-year rates of local and regional lymph node control were 92.5% and 100%, respectively. Eight-year probabilities of disease free, overall, and breast cancer specific survival were 84%, 52.5%, and 93.8%, respectively. There was minimal morbidity associated with either regional irradiation or tamoxifen.An approach to early breast cancer in the elderly that seeks to limit the aggressiveness of local and systemic therapies appears to result in a satisfactory disease outcome with few complications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ca7d4a2bc1840e8d487537ffa8a38302 https://pubmed.ncbi.nlm.nih.gov/8039115 Zobrazit plný text záznamu Plný text