| Autor: |
Chao, Hu, Jing, Zheng, Jia, Miao, Fang, Liu, Ting-Ting, Hu, Jing-Kai, Gu, Shi-Qing, Shu, Ying, Wang, Xiao-Hong, Zhu, Mao-Zhi, Liang |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 49(1) |
| ISSN: |
1672-173X |
| Popis: |
To compared the differences in pharmacokinetics of phosphate retagliptin tablets in patients with varying degrees of renal dysfunction.A total of 32 patients were categorized into five groups according to their renal function: normal,mild dysfunction, moderate dysfunction,severe dysfunction,and end stage renal dysfunction (ESRD). All of the patients took a single dose of 50 mg phosphate retagliptin tablet. Their plasma and urinary concentrations of phosphate retagliptin (SP2086) and phosphate retagliptin acid (SP2086 acid) were determined using LC-MS/MS methods. The plasma pharmacokinetic parameters were calculated using WinNolin 6.1 software.Peak concentrations (The dosage of phosphate retagliptin tablet is recommended at 100 mg/d for patients with normal renal function and those with mild renal dysfunction,at 50 mg/d for patients with moderate renal dysfunction,and at 25 mg/d for patients with severe renal dysfunction. No phosphate retagliptin tablet is recommended for patients with ESRD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
