| Autor: |
R C, Shumaker, K A, Robertson, I C, Hsu, J R, Allen |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Journal of the National Cancer Institute. 56(4) |
| ISSN: |
0027-8874 |
| Popis: |
Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite dehydroretronecine for 1 year. The animals were then observed for an additional 12 months for the induction of neoplasms. Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasized. In the 60 monocrotaline-treated rats, 31 widely dispersed tumors of various cell types were recorded. The reason suggested for the variation in tissue response was that the metabolite dehydroretronecine is a proximate carcinogen, whereas monocrotaline must first be metabolized before its carcinogenic potential is realized. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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