Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of β

Autor: Paula A da Costa, Martins, Janine M, van Gils, Anita, Mol, Peter L, Hordijk, Jaap J, Zwaginga
Rok vydání: 2005
Zdroj: Journal of leukocyte biology. 79(3)
ISSN: 1938-3673
Popis: Human monocytes adhere to activated platelets, resulting in the formation of platelet-monocyte complexes (PMC). Complex formation depends on the interaction between platelet-displayed P-selectin and the specific ligand for P-selectin on leukocytes, P-selectin glycoprotein ligand-1 (PSGL-1). We have recently shown that monocytes within PMC have increased adhesive capacity to the activated endothelium. To better understand the effect of platelet binding on the capacity of monocytes to adhere to activated endothelium, the P-selectin-PSGL-1 interaction-induced changes in integrin functionality were studied. The binding of platelets to monocytes via P-selectin-PSGL-1 interactions was shown to increase expression and activity of α
Databáze: OpenAIRE
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