| Autor: |
S, Hoşoglu, A, Ceviz, M S, Kemaloglu, I, Sari, S, Inalöz, M F, Geyik, O F, Kökoglu, C, Ayaz |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Acta microbiologica et immunologica Hungarica. 44(3) |
| ISSN: |
1217-8950 |
| Popis: |
It was investigated whether treatment with the calcium channels blocker Nimodipine, a 1,4-dihydropyridine derivative, influences vasculopathy and neuronal injury in experimental pneumococcal meningitis. Rats were randomly assigned to one of three experimental groups. The first group (Control group, n = 20) was given saline (0.4 ml/day) intraperitoneally (i.p.), whereas the second group (group C, n = 22) was treated only with ceftriaxone in a dosage of 30 mg/day/i.p.. The third group (group C-N, n = 22) was treated with the combination of ceftriaxone 30 mg/day/i.p., and nimodipine 0.6 mg/day/i.p.. Treatment was begun at the time of inoculation in all three groups. The control group was compared clinically and histopathologically with groups C and C-N at 24 h, three and six days after inoculation. Six rats in the control group and eight rats in group C and group C-N were sacrificed at 24 hours and seven rats in each group were sacrificed on the third and sixth day after inoculation. Clinically, there were no significant differences between group C and group C-N (p0.05). There were significant differences between group C and group C-N for vasculopathy and neuronal injury (p0.0001 and p0.005, respectively). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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