Hemostatic alterations in sickle cell disease: relationships to disease pathophysiology
| Autor: | M J, Stuart, B N, Setty |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Mice
Knockout Fibrinolysis Erythrocyte Membrane beta-Thalassemia Thrombin Erythrocytes Abnormal Thrombosis Anemia Sickle Cell Phosphatidylserines Platelet Activation Hemoglobinopathies Disease Models Animal Membrane Lipids Mice Erythrocyte Deformability Antibodies Antiphospholipid Cell Adhesion Animals Humans Thrombophilia Endothelium Vascular |
| Zdroj: | Pediatric pathologymolecular medicine. 20(1) |
| ISSN: | 1522-7952 |
| Popis: | The protean manifestations of sickle cell disease (SCD), especially, microvessel involvement in the vaso-occlusive process, is classically ascribed to the phenomena of erythrocyte sickling and enhanced red cell-endothelial adherence. Pertubations in various hemostatic systems occurs in SCD, both in steady state and during vaso-occlusion, with the intravascular generation of thrombin. The etiology(s) of thrombin generation in SCD will be described. Whether the activation of the cellular and plasmatic phases of hemostasis is causative or occurs as a result of vascular injury will be discussed. |
| Databáze: | OpenAIRE |
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