| Autor: |
G, Ozen, S, Boumiza, C, Deschildre, G, Topal, D, Longrois, P J, Jakobsson, J B, Michel, M P, Jacob, K, Chahed, X, Norel |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
International journal of obesity (2005). 43(9) |
| ISSN: |
1476-5497 |
| Popis: |
Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft failure of coronary artery (CA) bypass grafts [internal mammary artery (IMA), saphenous vein (SV)]. In these inflammatory conditions, the release of prostaglandin EMMP-1,-2 and TIMP-1,-2 densities were measured in human plasma (n = 68) as well as in supernatants of human vascular wall (IMA n = 16, SV n = 14, CA n = 13) and their PVAT. The effects of inflammation and mPGES-1 inhibitor (Compound III, 10 µM) on MMPs regulation were evaluated. The correlations between PGEThe vascular wall and PVAT from SV exhibited the greatest MMP-1,-2 release. An increase of MMP-1,-2 and/or a decrease of TIMP-1 quantities have been detected under inflammation only in vascular wall not in PVAT. These changes under inflammation were completely reversed by inhibition of mPGES-1. In obesity, C-reactive protein (CRP), biomarker of inflammation, and PGEThe greater MMP activity observed in SV may contribute to the increased prevalence of graft failure. Under inflammation, the greater mPGES-1 and PGE |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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