[Can extended induction chemoradiotherapy be effective in the combined treatment of stage IIIB Hodgkin's disease ?]

Autor:	S V, Kanaev, M M, Girshovich, S G, Golovanov, M L, Gershanovich
Rok vydání:	2009
Předmět:	Adult Male Remission Induction Radiotherapy Dosage Middle Aged Hodgkin Disease Disease-Free Survival Drug Administration Schedule Treatment Outcome Chemotherapy Adjuvant Antineoplastic Combined Chemotherapy Protocols Humans Female Radiotherapy Adjuvant Lymph Nodes Aged Neoplasm Staging
Zdroj:	Voprosy onkologii. 55(5)
ISSN:	0507-3758
Popis:	The paper evaluates the results of chemoradiaton (2-4 cycles of preliminary treatment to suppress intoxication symptoms plus total, or subtotal exposure of the lymph nodes to tumor-killing doses in cases of intact iliac inguinal nodes) in 89 patients with Hodgkin's disease stage IIIB. The data are evaluated vis-à-vis regression in exposed foci as intoxication symptoms receded. Overall survival was significantly lower (p = 0.044) when tumor regression was well below 75%. Similar trends were reported with regard to relapse-free survival. It is concluded that, with our regimen, combined treatment will not be effective unless 75% or more regression of tumor is assured.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c9880778a29a27b81737a8b2ae3e20f3 https://pubmed.ncbi.nlm.nih.gov/20020650 Zobrazit plný text záznamu