Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis
| Autor: | M M, Kheir, O Z, Baraka, I A, el-Tom, M M, Mukhtar, M M, Homieda |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Anthelmintics Liver Cirrhosis Adolescent Endemic Diseases Incidence Infant Middle Aged Esophageal and Gastric Varices Severity of Illness Index Praziquantel Schistosomiasis mansoni Sudan Age Distribution Cause of Death Child Preschool Population Surveillance Splenomegaly Prevalence Humans Morbidity Child Parasite Egg Count Hepatomegaly |
| Zdroj: | Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. 6(5-6) |
| ISSN: | 1020-3397 |
| Popis: | The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection (or = 400 eggs/g of faeces) from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high (community-wide, up to 11/100 infected patients with bleeding). Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution. |
| Databáze: | OpenAIRE |
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