Evaluation of doxorubicin-induced early multi-organ toxicity in male CD1 mice by biodistribution of

Autor: Julio César, Córdoba-Adaya, Rigoberto, Oros-Pantoja, Eugenio, Torres-García, Enrique, Morales-Ávila, Liliana, Aranda-Lara, Jonnathan G, Santillán-Benítez, Neri O, Hernández-Herrera, Gloria, Otero, Keila, Isaac-Olivé
Rok vydání: 2021
Předmět:
Zdroj: Toxicology mechanisms and methods. 31(7)
ISSN: 1537-6524
Popis: The search for methods that identify early toxicity, induced by chemotherapy, is urgent. Changes in the biodistribution of radiopharmaceuticals could give information on early toxicity. Ten-week-old CD1 male mice were divided into four groups. Two groups were administered a weekly dose of 5 mg/kg of doxorubicin hydrochloride (DOX) for 5 weeks and the control groups were administered saline solution. One week after the end of treatment, the biodistribution of
Databáze: OpenAIRE