Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG

Autor:	Aarti V, Shah, Graeme M, Birdsey, Anna M, Randi
Rok vydání:	2016
Předmět:	Endothelial homeostasis genetic structures Neovascularization Physiologic Vascular development Review eye diseases Gene Expression Regulation Transcriptional Regulator ERG Gene transcription Animals Homeostasis Humans ETS transcription factors sense organs Endothelium Vascular Angiogenesis
Zdroj:	Vascular Pharmacology
ISSN:	1879-3649
Popis:	Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial functions, while repressing expression of pro-inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis. This review summarises the main roles and pathways controlled by ERG in the vascular endothelium, its transcriptional targets and its functional partners and the emerging evidence on the pathways regulating ERG's activity and expression. Graphical abstract ERG regulation of endothelial function and homeostasis.Image 1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c8bebc2cd63cb2f29a7a24388631784b https://pubmed.ncbi.nlm.nih.gov/27208692 Zobrazit plný text záznamu Full Text from ScienceDirect