Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas
| Autor: | Irianiwati, Widodo, Ery Kus, Dwianingsih, Totok, Utoro, Sumadi Lukman, Anwar, Teguh, Aryandono, Soeripto, Soeripto |
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| Rok vydání: | 2018 |
| Předmět: |
Vascular Endothelial Growth Factor C
Breast carcinoma Breast Neoplasms Middle Aged Prognosis Vascular Endothelial Growth Factor Receptor-3 Survival Rate lymphangiogenesis Indonesia Lymphatic Metastasis luminal and non-luminal subtype Humans Female Prospective Studies VEGF-C-survival Lymphatic Vessels Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Background: Breast carcinomas (BCs) are sub-classified according to the molecular characteristics into luminal and non-luminal subtypes that clinically show different biological behavior, treatment and prognosis. BCs spread primarily through lymphatic vessels using cascade processes of lymphagiogenesis in which VEGF-C plays an important role during lymph node metastasis. Prognostic value of VEGF-C in luminal and non-luminal BC is still unclear and has not been studied thoroughly to clarify and define prognosis and therapeutic monitoring. Aim: To define the prognostic value of lymphangiogenesis on survival rates of luminal and non-luminal subtypes BC. Materials and Methods: This study applied prospective cohort design, using 130 patients of invasive duct carcinoma of the breast, stage I-IIIA, from Sardjito General Hospital, Indonesia and subsequent longitudinal follow-up. Immunohistochemical staining was carried out using anti-ER, -PR, -Her-2, VEGF-C, VEGFR-3 and D2-40 antibodies. The related clinicopathologic characteristics of BC patients and lymphangiogenesis determinants, including VEGF-C expression, were statistically analyzed. Results: In non-luminal BC subtypes, VEGF-C expression (HR=0.04; 95% CI=0.01-0.41), lymph node metastasis (HR=0.14; 95% CI=0.04-0.55) and stage (HR=0.30; 95% CI= 0.02-0.76) were determined as independent prognostic factors on survival rates. However, the lymphangiogenesis determinants were not associated with the survival rates of luminal BC subtypes. Conclusion: This study suggested that lymphangiogenesis affects survival rates of non-Luminal subtype rather than the luminal subtypes of BC. |
| Databáze: | OpenAIRE |
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