| Autor: |
G, Rostoker, V, Wirquin, H, Terzidis, M, Petit-Phar, M T, Chaumette, J C, Delchier, D, Belghiti, P, Lang, J M, Dubert, M, Meignan |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Nephron. 63(3) |
| ISSN: |
1660-8151 |
| Popis: |
To study the specificity of gut hyperpermeability in primary glomerulonephritis, we investigated intestinal permeability by means of 51Cr-EDTA testing in 20 healthy individuals and in 30 patients with Immunoglobulin A nephropathy (IgA GN), 25 with idiopathic nephrotic syndrome (INS) and 20 with immune complex glomerulonephritis (IC-GN; membranous+membranoproliferative glomerulonephritis). Gut permeability was statistically increased in each patient group versus the controls [controls: 2% (0.4-3.9); IgA GN: 3.25% (0.7-17.70); INS: 3.71% (0.82-10); IC-GN: 3.40% (0.30-16); results are median (range); p0.005, nonparametric Mann-Whitney test]. An increase in intestinal permeability exceeding the upper limit of control values (95th percentile) was observed in 36% of IgA GN, 60% of INS and 50% of IC-GN patients. We conclude that intestinal permeability is frequently increased in primary glomerulonephritis and may also be increased in types of glomerulonephritis other than IgA GN. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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