| Autor: |
A, Seiser, G, Pötzl, G, Safoschnik, S, Pichler, H, Bernheimer, B, Schwerer |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Wiener klinische Wochenschrift. 106(6) |
| ISSN: |
0043-5325 |
| Popis: |
IgA, IgG, and IgM antibodies against ganglioside GM 1 were investigated in sera of 15 patients with Guillain-Barré syndrome (GBS), as compared with healthy controls. Significantly raised titers were found in 4 patients who showed persisting weakness due to muscle wasting (3 patients) or due to the development of a chronic relapsing form of GBS (1 patient) after a follow up period of 1 year. By contrast, only 1 out of 11 anti-GM 1 seronegative patients showed persisting muscle wasting. In 1 patient with GBS following Campylobacter jejuni enteritis an IgA anti-GM 1 immune response was found to predominate, suggesting that this immune response may be due to crossreactivity between GM 1 and Campylobacter antigens. We conclude that elevated antibody titers against ganglioside GM 1 may be a valuable marker to predict poor motor recovery in GBS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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