Pharmacokinetics and bioavailability of a metformin/glyburide tablet administered alone and with food

Autor:	P H, Marathe, M E, Arnold, J, Meeker, D S, Greene, R H, Barbhaiya
Rok vydání:	2001
Předmět:	Adult Male Food-Drug Interactions Cross-Over Studies Adolescent Glyburide Biological Availability Humans Hypoglycemic Agents Female Metformin Tablets
Zdroj:	Journal of clinical pharmacology. 40(12 Pt 2)
ISSN:	0091-2700
Popis:	Two randomized crossover studies were conducted to evaluate the pharmacokinetics (including food effect) of fixed-combination metformin/glyburide tablets. Pharmacokinetics and bioavailability of two strengths (500 mg/2.5 mg and 500 mg/5 mg) of metformin/glyburide tablets were assessed relative to coadministered metformin and glyburide tablets in study 1. The effect of a high-fat meal on the bioavailability of a metformin/glyburide (500 mg/5 mg) tablet was assessed relative to the fasted condition in study 2. The fixed combination metformin/glyburide tablets showed bioequivalence for the metformin component with the reference metformin tablet and comparable bioavailability for the glyburide component with the reference glyburide tablet. Food does not appear to affect the bioavailability of either component to an appreciable extent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c85bab22b0d70e95bdf1b1088ee43d54 https://pubmed.ncbi.nlm.nih.gov/11185672 Zobrazit plný text záznamu Plný text