Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke

Autor:	Azab, Seham F., Akeel, Nagwa E., Abdalhady, Mohamed A., Elhewala, Ahmed A., Ali, Al Shymaa A., Amin, Ezzat K., Sarhan, Dina T., Almalky, Mohamed A.A., Elhindawy, Eman M., Salam, Mohamed M.A., Soliman, Attia A., Abdellatif, Sawsan H., Ismail, Sanaa M., Elsamad, Nahla A., Hashem, Mustafa I.A., Aziz, Khalid A., Elazouni, Osama M.A., Arafat, Manal S.
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Male Adolescent Interleukin-6 Injections Subcutaneous Observational Study Infant Enzyme-Linked Immunosorbent Assay Brain Ischemia Stroke Hepcidins Child Preschool Acute Disease Ferritins Receptors Transferrin Humans Female Enoxaparin Child Research Article
Zdroj:	Medicine
ISSN:	1536-5964 0025-7974
Popis:	Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of iron homeostasis. Despite the growing evidence of iron imbalance in childhood-onset ischemic stroke, serum hepcidin level in those patients has not yet been researched. In this study, we aimed to estimate serum (hepcidin) level in acute ischemic stroke (AIS) patients and to investigate whether subcutaneous enoxaparin sodium, which is a low-molecular-weight heparin (LMWH) derivative, could modulate serum hepcidin level in those patients. This was a case–control study included 60 (AIS) cases, and 100 healthy children with comparable age and gender as control group. For all subjects’ serum hepcidin, interleukin-6 (IL-6), and soluble transferrin receptor [sTfR]) levels were assessed by (enzyme-linked immunosorbent assay [ELISA] method). Iron parameters including (serum iron, ferritin, transferrin, and total iron binding capacity [TIBC]) were also measured. The patients were subdivided according to treatment with an LMWH derivative into 2 groups and serum hepcidin levels were assessed initially and 1 week after stroke onset for all cases. We found that AIS cases had higher serum iron, ferritin, and IL6 levels compared to the control group (all P 0.05). However, on the 7th day of diagnosis serum hepcidin level decreased significantly in AIS cases treated with LMWH (group 1) (median, 36 vs 21 ng/mL; P 0.05). Serum hepcidin showed significant positive correlations with serum iron, transferrin saturation, ferritin, and IL6 (r = 0.375, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c845d63d2c157d5c878dc13bdce1f36b http://europepmc.org/articles/PMC4782878 Zobrazit plný text záznamu