| Autor: |
Patricia, Lam, Chitra, Vinnakota, Beatriz Calvo-Flores, Guzmán, Julia, Newland, Katie, Peppercorn, Warren P, Tate, Henry J, Waldvogel, Richard L M, Faull, Andrea, Kwakowsky |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Molecules (Basel, Switzerland). 27(8) |
| ISSN: |
1420-3049 |
| Popis: |
Alzheimer's disease (AD) is a neurodegenerative disorder with an increasing need for developing disease-modifying treatments as current therapies only provide marginal symptomatic relief. Recent evidence suggests the γ-aminobutyric acid (GABA) neurotransmitter system undergoes remodeling in AD, disrupting the excitatory/inhibitory (E/I) balance in the brain. Altered expression levels of K-Cl-2 (KCC2) and N-K-Cl-1 (NKCC1), which are cation-chloride cotransporters (CCCs), have been implicated in disrupting GABAergic activity by regulating GABA |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
