[Role of increased tissue pressure in the pathophysiology of osteoarthritis]

Autor:	C, Fricker, G, Stuker, P, Schawalder
Jazyk:	němčina
Rok vydání:	2012
Předmět:	Osmotic Pressure Osteoarthritis Animals Humans Joints Models Biological Bone and Bones
Zdroj:	Zeitschrift fur Rheumatologie. 71(9)
ISSN:	1435-1250
Popis:	Osteoarthritis is characterized by increased internal pressure in the subchondral bone tissue as well as in the joint capsule. In analogy to the pathophysiological mechanism of venous compartment syndrome it is demonstrated that the increased pressure is maintained by high protein edema and initiates a vicious circle. Drug-induced resorption of the osmotically active proteins leads to elimination of the high protein edema and is able to interrupt the pathophysiological process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c7a8a5ba6a7f77419b85a555e278cdaa https://pubmed.ncbi.nlm.nih.gov/22932981 Zobrazit plný text záznamu Full text from SpringerLink