Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?

Autor:	Huub P C, Van Kuringen, Joke, Lenoir, Els, Adriaens, Johan, Bender, Bruno G, De Geest, Richard, Hoogenboom
Rok vydání:	2012
Předmět:	Chromatography Gas Gastric Juice Magnetic Resonance Spectroscopy Cell Survival Hydrolysis Gastropoda Temperature Biocompatible Materials Fibroblasts Mucus Biomimetic Materials Thermogravimetry Polyamines Animals Humans Hydrochloric Acid Cells Cultured
Zdroj:	Macromolecular bioscience. 12(8)
ISSN:	1616-5195
Popis:	The hydrolysis of PEtOx is studied to evaluate the potential toxicity of partially hydrolyzed polymers that might interfere with its increasing popularity for biomedical applications. The hydrolysis of PEtOx is studied in the presence of digestive enzymes (gastric and intestinal) and at 5.8 M hydrochloric acid as a function of temperature (57, 73, 90, and 100 °C). It is found that PEtOx undergoes negligible hydrolysis at 37 °C and that thermal and solution properties are not altered when up to 10% of the polymer backbone is hydrolyzed. Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c78b3532b323e1aa8fa18d514ceb2d76 https://pubmed.ncbi.nlm.nih.gov/22777761 Zobrazit plný text záznamu Plný text