Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H
| Autor: | Salvador, Harguindey, Khalid, Alfarouk, Julián, Polo Orozco, Stefano, Fais, Jesús, Devesa |
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| Rok vydání: | 2020 |
| Předmět: |
H+-related therapeutics of breast cancer
Sodium-Hydrogen Exchangers Cell Respiration Intracellular Space Antineoplastic Agents Breast Neoplasms Review Translational Research Biomedical Biomarkers Tumor Tumor Microenvironment Animals Humans Molecular Targeted Therapy pH-related paradigm Cation Transport Proteins Clinical Studies as Topic Disease Management Proton Pump Inhibitors Hydrogen-Ion Concentration Proton Pumps Combined Modality Therapy breast cancer etiopathogenesis breast cancer treatment Treatment Outcome Drug Resistance Neoplasm Female hydrogen ion dynamics of cancer Protons Hydrogen |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced. |
| Databáze: | OpenAIRE |
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